Validation of the Antidiabetic and Hypolipidemic Effects of Hawthorn by Assessment of Gluconeogenesis and Lipogenesis Related Genes and AMP-Activated Protein Kinase Phosphorylation

Figure 1

Effects of extract of hawthorn on (a) plasma glucose, (b) triglyceride, (c) total cholesterol, and (d) HDL levels at week 12. Mice were fed 45% high-fat diet (HF) or low-fat diet (CON) for 12 weeks. At 8 weeks following HF, the HF mice were treated with vehicle (water; p.o.) or extracts of hawthornor rosiglitazone (p.o.) accompanied with HF diet for 4 weeks. All values are means ± S.E. (𝑛=9). ^#𝑃<0.05 compared with the control (CON) group; ^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001 compared with the high-fat + vehicle (distilled water) (HF) group by ANOVA.

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