Therapeutic Effect of Chung-Pae, an Experimental Herbal Formula, on Acute Lung Inflammation Is Associated with Suppression of NF-κB and Activation of Nrf2
Figure 4
Aerosol intratracheal Chung-pae administration suppresses acute neutrophilic lung inflammation in LPS-induced ALI animal model. (a) H&E stained lung sections of C57BL/6 mice. C57BL/6 mice received sham (top panels) or an i.p. injection of LPS (bottom panels). At 2 h after the treatments, mice received 20 mg/kg (top 2nd panel and bottom 3rd panel) or 5 mg/kg (bottom 2nd panel) of CP in aerosol via trachea. At 24 h after LPS administration, the lungs of mice were analyzed by histological examination. Data are representatives of at least five different areas of a lung (200x magnifications). Total cells (b) and neutrophils and macrophages (c) in BAL fluid were scored. * was less than 0.05, compared to the mice treated with LPS only. Data are presented as the mean ± SEM of 5 mice per group.