Evidence-Based Complementary and Alternative Medicine

Review Article

An Update on Antitumor Activity of Naturally Occurring Chalcones

Table 2

Chalcones and their mechanisms.
ChalconesMechanismsReference
Cardamonin (9)Induction of apoptosis[47]
Flavokawain A (16)[6]
Flavokawain B (2)[50–52]
Ashitaba chalcone (43)[53]
Isolespeol (68)[26]
Boesenbergin A (65)[57]
Millepachine (66)[25]
2′,6′-dihydroxy-4′-methoxychalcone (14)[45]
2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone (7)Induction of apoptosis[54]
Antiangiogenesis[120]
Isoliquiritigenin (12)Induction of apoptosis[4, 48, 55]
Induction of apoptosis under hypoxia[64]
Chemoprevention[78–81]
Cell signal transduction[93]
Antimetastasis[109]
Regulation of cell cycle[112–116]
Redifferentiation[126]
Supplement for cisplatin chemotherapy[127]
Xanthoangelol (44) Induction of apoptosis[39, 56]
Chemoprevention[85]
Antimetastasis[107]
Isobavachalcone (42) Induction of apoptosis[44, 58]
Chemoprevention[85, 86]
Cell signal transduction[94]
Antimetastasis[106]
Xanthohumol (49) Induction of apoptosis [44, 59]
Induction of apoptosis under hypoxia[65]
NF-κB pathway[70–73]
Chemoprevention[90, 92]
Cell signal transduction[98]
Antiinvasion[101–104]
Antiangiogenesis[121–125]
Panduratin A (74) Induction of apoptosis [40]
NF-κB pathway[74]
Regulation of cell cycle[111]
Butein (1)Induction of apoptosis [43, 44]
NF-κB pathway[69]
Chemoprevention[77]
Cell signal transduction[95]
Fibroblasts[128]
Licochalcone A (35)Induction of apoptosis[44]
Regulation of cell cycle[119]
Sanggenon O (88), C (89), kuwanon J (90), Q (91), R (92), V (93)Induction of apoptosis under hypoxia[63]
Naringenin chalcone (19), isosalipurposide (18)Cell signal transduction[96]
Xanthoangelol F (48)Chemoprevention[85]
Isoliquiritin apioside (22)[91]
Xanthoangelol I (64), J (49),[86]
Xanthoangelol H (63)Induction of apoptosis[58]
Chemoprevention[85]
1,2-dihydroparatocarpin A (70)Chemoprevention[83]
4-hydroxyderricin (47)Chemoprevention[85]
Antimetastasis[108]
2′-hydroxy-2,3,4′,6′-tetramethoxychalcone (21)Regulation of cell cycle[117, 118]
Isocordoin (40)Cell signal transduction[97]
Regulation of cell cycle[27]
Kanzonol C (45), 4-hydroxylonchocarpin (56)Antimetastasis[105]
Paratocarpin C (53), stipulin (46), dorsmannin A (57)[106]
Pauferrol A (99)DNA topoisomerase II[129]