Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells

<table>Cytotoxic effect of shikonin against U937 leukemia cells. (a) Chemical structure of shikonin. (b) Dose response curves of U937 cells after treatment with different concentrations of shikonin. Resazurin reduction assays were performed to determine dose response curve. Viability of U937 cells is represented by mean ± SEM of three independent experiments, and it is expressed as percentage survival of control.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 1: Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells 

Figure 1 | Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells 