Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells

<table>Dose response curve of shikonin in an IGF1-R kinase assay. A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of IGF1R. IC50 values were calculated by nonlinear regression using Prism 5.04 (Graphpad, CA, USA).</table>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells 

Figure 5 | Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells 