Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5

Figure 1

Representative selective ion current chromatograms of the BAC (a), BMA (b), and BHA (c) metabolites in HLMs incubated with 10 μM of the parent compound for 120 min at 37°C. A total of 7, 8, and 9 metabolites were observed for BAC, BMA, and BHA after incubation with HLMs and NADPH, respectively.