Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5
Figure 2
Effects of CYP enzyme chemical inhibitors on BAC (a), BMA (b), and BHA (c) metabolism. BAC, BMA, or BHA (10 μM) was incubated with HLMs and NADPH-regenerating system in the presence of 5 μM chemical inhibitors for 120 min at 37°C. In the control experiments, equivalent amounts of solvent were used in place of the inhibitors. Each column represents the mean of three formation rate determinations for the metabolites, and the error bars represent the standard deviation of the mean. Statistically significant differences compared with the control () are marked with asterisks (*).
