Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5
Figure 3
Effects of CYP enzyme mAbs on BAC (a), BMA (b), and BHA (c) metabolism. BAC, BMA, or BHA (10 μM) was incubated with HLMs and NADPH-regenerating system in the presence of various individual mAbs for 120 min at 37°C. Equivalent amounts of Tris buffer were used instead of mAbs in the control experiments. Each column represents the mean of three formation rate determinations for the metabolites, and the error bars represent standard deviation of the mean. Statistically significant differences compared with the control () are marked with asterisks (*).
