Dissection of Mechanisms of a Chinese Medicinal Formula: Danhong Injection Therapy for Myocardial Ischemia/Reperfusion Injury In Vivo and In Vitro

Figure 3

Protective effect of A, B, C, and DHI on SI/R-induced cytotoxicity in neonatal rat cardiomyocytes. (a) Chemical structures of A, B, and C, respectively. (b) Effects of A, B, C, and DHI on SI/R-induced reduction of cell viability. (c) Effects of A, B, C, and DHI on LDH activity in the cultured supernatants of cardiomyocytes subjected to SI/R. LDH, lactate dehydrogenase; SI/R, simulated ischemia/reperfusion; A, hydroxysafflor yellow A; B, salvianolic acid B; C, danshensu; DHI, Danhong injection. Data are presented as mean ± SD of 3 independent experiments. ^##𝑃<0.01 versus control; *𝑃<0.05,**𝑃<0.01 versus SI/R.

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