Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats

Figure 3

Modulation by ethanolic extract of Andrographis paniculata (APE) and andrographolide (AND) of hepatic CYP isozyme protein (a) and mRNA (b) expression. Rats were orally administered methyl cellulose (Con), APE, or AND for 5 days. Total RNA and microsomal proteins were prepared as described in Section 2. Protein and mRNA levels in pooled liver samples (𝑛=5) are shown. Values shown are the mean ± SD, 𝑛=5. The significance of the difference among group means was determined by one-way ANOVA followed by Tukey’s test. Values of treatments not sharing the same letter differ significantly, 𝑃<0.05.

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