Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats

Table 1

Effects of ethanolic extract of Andrographis paniculata (APE) and andrographolide (AND) on the body weight, liver weight, and plasma aminotransferases of rats.

	Control	APE	AND
Body weight (g)
Initial	271±16	272±7	272±8
Final	337±10^a	307±12^b	332±13^a
Liver weight (g)	14.4±1.2	13.3±0.7	12.8±1.5
Relative liver weight (%)	4.3±0.4	4.3±0.4	3.8±0.3
Plasma aminotransferases (U/L)
AST	24.8±5.4	23.5±5.7	27.7±4.4
ALT	14.7±2.4	12.9±2.2	15.8±8.2

Rats were orally dosed daily with 2 g/kg of APE or 50 mg/kg of AND for 5 days. Relative liver weight = (liver weight/ body weight) × 100. AST: aspartate aminotransferase; ALT: alanine aminotransferase. The values represent the mean ± SD, 𝑛=5. The significance of the difference among group means was determined by one-way ANOVA followed by Tukey’s test. ^abValues of treatments not sharing the same letter differ significantly, 𝑃<0.05.