Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats

Table 2

Effects of ethanolic extract of Andrographis paniculata (APE) and andrographolide (AND) on the pharmacokinetic parameters of tolbutamide.

	Control	APE	AND
AUC0--12h, (𝜇g/mL × h)	1393±262^a	881±152^b	1143±123^ab
𝑇max, h	1.6±0.5	1.5±0.6	1.0±0.5
𝐶max, 𝜇g/mL	151±21	133±21	140±8
MRT, h	7.9±1.6^a	6.0±1.5^b	8.4±1.1^a

Rats were orally dosed daily with 2 g/kg of APE or 50 mg/kg of AND for 5 days. On day 6, a 20 mg/kg oral dose of tolbutamide was administered. AUC: area under the plasma drug concentration curve; 𝐶_max: the maximum plasma drug concentration; 𝑇_max: time to achieve 𝐶_max; MRT: mean resident time. The values represent the mean ± SD, 𝑛=5. The significance of the difference among group means was determined by one-way ANOVA followed by Tukey’s test. ^abValues of treatments not sharing the same letter differ significantly, 𝑃<0.05.