<i>Persea declinata</i> (Bl.) Kosterm Bark Crude Extract Induces Apoptosis in MCF-7 Cells via  <b>G<sub>0</sub>/G<sub>1</sub></b> Cell Cycle Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation

<table>(a) Representative images of MCF-7 cells treated with DMEM, doxorubicin, or PDM for 24 h and stained with Hoechst 33342 for nuclear, membrane permeability, and mitochondrial membrane potential (MMP) dyes. PDM induced a noteworthy elevation in membrane permeability and a marked reduction in MMP (magnification: 200x). (b) Representative bar charts indicating dose-dependent increased cell permeability and reduced MMP in the PDM-treated MCF-7 cells.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 5

Figure 5: <i>Persea declinata</i> (Bl.) Kosterm Bark Crude Extract Induces Apoptosis in MCF-7 Cells via  <b>G<sub>0</sub>/G<sub>1</sub></b> Cell Cycle Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation 

Figure 5 | Persea declinata (Bl.) Kosterm Bark Crude Extract Induces Apoptosis in MCF-7 Cells via  G0/G1 Cell Cycle Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation 