Shenfu Injection for Intradialytic Hypotension: A Systematic Review and Meta-Analysis
Table 2
Grade Quality of evidence of SFI for IDH.
Outcomes
Illustrative comparative risks* (95% CI)
Relative effect (95% CI)
No of Participants (studies)
Quality of the evidence (GRADE)
Assumed risk
Corresponding risk
Control
Shenfu
Systolic blood pressure Follow-up: 3–12 w
The mean systolic blood pressure in the intervention groups was 22.64 higher (17.35 to 27.94 higher)
128 (3 studies)
⊕⊕⊝⊝ Low1
Diastolic blood pressure Follow-up: 3–12 w
The mean diastolic blood pressure in the intervention groups was 16.8 higher (2.59 lower to 36.18 higher)
122 (3 studies)
⊕⊝⊝⊝ Very low1,2
The clinical effective rate Follow-up: 3–12 w
Study population
RR 1.29 (1.19 to 1.4)
530 (2 studies)
⊕⊕⊝⊝ Low1
737 per 1000
951 per 1000 (877 to 1000)
Moderate
724 per 1000
934 per 1000 (862 to 1000)
Hypotension incidence
Study population
RR 0.57 (0.47 to 0.7)
7348 (7 studies)
334 per 1000
190 per 1000 (157 to 234)
Moderate
427 per 1000
243 per 1000 (201 to 299)
Hypotension incidence-Prevention Follow-up: 3–12 w
Study population
RR 0.46 (0.36 to 0.58)
2648 (4 studies)
⊕⊝⊝⊝ Very low1,2
426 per 1000
196 per 1000 (153 to 247)
Moderate
439 per 1000
202 per 1000 (158 to 255)
Hypotension incidence-Treatment Follow-up: 3–12 w
Study population
RR 0.72 (0.58 to 0.91)
4700 (3 studies)
⊕⊝⊝⊝ Very low1,2
272 per 1000
196 per 1000 (158 to 248)
Moderate
226 per 1000
163 per 1000 (131 to 206)
ALB Follow-up: 3 months
The mean alb in the intervention groups was 3.15 higher (1.87 to 4.42 higher)
192 (4 studies)
⊕⊕⊝⊝ Low1
CRP Follow-up: 3 months
The mean crp in the intervention groups was 2.42 lower (3.4 to 1.44 lower)
140 (3 studies)
⊕⊕⊝⊝ Low1
None of the trials were blinded or allocation concealed.
2Confidence intervals with minimal overlap, the value for heterogeneity is less than 0.05 and > 50%. Heterogeneity was not explained. Means hemodialysis sessions, as they need dialysis twice or thrice in every week.
