The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels

Table 1

Effect of diazepam and valtrate on the behavior of rats in the elevated plus-maze test.

Group	Dose (mg/kg)	Open arm entries	Closed arm entries	Total arm entries	Time in open arms (s)	Time in closed arms (s)
Vehicle	—	3.07±0.59	9.16±0.95	10.07±1.45	48.41±4.36	189.94±10.57
Diazepam	1	4.80±0.73	9.70±0.76	12.20±0.97	98.92±10.07	138.55±9.54
Valtrate	5	2.00±0.29	10.71±0.97	9.50±1.59	52.21±8.09	183.31±15.45
	10	6.36±1.16	10.55±1.23	13.33±1.41	87.20±10.20	143.13±8.92
	20	4.22±0.47	8.78±0.70	11.75±1.11	82.01±8.69	147.51±8.68