Pharmacokinetic Alteration of Baclofen by Multiple Oral Administration of Herbal Medicines in Rats

Figure 3

Schematic diagram of the pharmacokinetic model for baclofen. The model consisted of two compartments and first-order absorption of baclofen. , , , and = amount of drug in the gut, central, peripheral, and urine compartments, respectively; = first-order absorption rate constant; and = intercompartmental rate constants between the central () and peripheral () compartments for baclofen; and = drug elimination rates into the urine and other processes, respectively.