Protective Effect of Flos Lonicerae against Experimental Gastric Ulcers in Rats: Mechanisms of Antioxidant and Anti-Inflammatory Action

Table 1

Antiulcerogenic activities of GC-7101 for acute and subchronic gastric ulcers.

Experimental models	Treatment	Dose	Gastric lesion	Inhibition (%)
HCl/EtOH	Vehicle	—	81.8 ± 12.0	—
	Ranitidine	30	40.3 ± 7.9	50.7
	Rebamipide	30	35.0 ± 8.3	57.2
	GC-7101	25	40.5 ± 6.8	50.5
		50	32.8 ± 4.4	60.0
		100	41.9 ± 8.4	48.8
Indomethacin	Vehicle	—	35.6 ± 5.3	—
	Ranitidine	30	3.6 ± 0.9	89.8
	Rebamipide	30	12.0 ± 2.1	66.4
	GC-7101	25	13.1 ± 2.1	63.3
		50	12.0 ± 2.1	66.4
		100	9.6 ± 4.9	72.9
Water immersion restraint stress	Vehicle	—	21.1 ± 2.1	—
	Ranitidine	30	7.5 ± 1.1	64.4
	Rebamipide	30	13.4 ± 1.5	36.6
	GC-7101	25	10.9 ± 1.4	48.3
		50	8.4 ± 1.1	60.2
		100	8.3 ± 1.5	60.6
Acetic acid	Vehicle	—	20.0 ± 1.5	—
	Ranitidine	30	10.3 ± 1.1	48.4
	Rebamipide	30	8.4 ± 1.5	57.7
	GC-7101	25	8.9 ± 1.7	55.6
		50	8.5 ± 1.9	57.6
		100	5.3 ± 0.8	73.7

The values are represented as means ± SEM for eight to ten rats per group. Significantly different (P < 0.05, P < 0.01) from vehicle-treated rats.