Research Article
Topical Antinociceptive Effect of Vanillosmopsis arborea Baker on Acute Corneal Pain in Mice
Table 1
Pharmacologic agents used for test in order to verify the possible action mechanism of EOVA antinociceptive effect.
| | Drug | Target | Dose
(mg/kg) | Administration
route |
| | Naloxone | Opioid receptors | 2 (11) | Intraperitoneal | | Prazosin | -receptors | 0.15 (12) | Intraperitoneal | | Yohimbine | -receptors | 2 (11) | Intraperitoneal | | Theophylline | Adenosine receptors | 5 (13) | Intraperitoneal | | L-NAME | NO synthesis | 2 (11) | Intraperitoneal | | Ondansetron | 5-HT3 receptors | 0.5 (14) | Intraperitoneal | | Atropine | Muscarinic receptors | 0.1 (15) | Intraperitoneal | | Glibenclamide | channels | 2 (16) | Intraperitoneal | | Ruthenium red | TRPV1 receptors | 5 (13) | Intraperitoneal | | (noncompetitive antagonist) | | 3 (11, 17, 18) | Subcutaneous | | Capsazepine (competitive antagonist) | | 5 (16) | Intraperitoneal |
|
|
