The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA/1J Mouse Rheumatoid Arthritis

Figure 3

Platycodin D reduced clinical arthritis scores and paw and knee thickness in platycodin D-treated CIA mice. (a) Decreases of clinical arthritis scores were detected in platycodin D treated mice as compared with CIA control mice. (b) Paw thickness was reduced in platycodin D treated mice as compared with CIA control mice. (c) Knee thickness was reduced in platycodin D treated mice as compared with CIA control mice. Values are expressed as means ± SD (𝑛=8); ^a𝑃<0.05 in platycodin D 200 mg/kg treated mice, bin platycodin D 100 and 50 mg/kg treated mice as compared with CIA control mice. AC: day of antigen challenge at 23 days after immunization. All animals were fasted overnight before immunization.

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