The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA/1J Mouse Rheumatoid Arthritis

Figure 4

Platycodin D had a therapeutic effect on the CIA mice mediated by anti-inflammatory, antioxidative, and immunomodulatory effects. (a) Paw MPO and MDA contents of platycodin D-treated mice were lower compared to CIA control mice. (b) Paw TNF-α and IL-6 levels in platycodin D-treated mice were lower compared with CIA control mice. (c) Splenocyte TNF-α and IL-6 levels in platycodin D-treated mice were lower compared with CIA control mice. Values are expressed as means ± SD (𝑛=8); ^a𝑃<0.01 as compared with intact control by LSD test; ^b𝑃<0.01 as compared with CIA control by LSD test; ^c𝑃<0.01 and ^d𝑃<0.05 as compared with intact control by MW test; ^e𝑃<0.01 and ^f𝑃<0.05 as compared with CIA control by MW test.

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(b)

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