The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA/1J Mouse Rheumatoid Arthritis

Table 1

Changes of left hind paw and secondary lymphatic organs detected after treatment of Enbrel and three different dosages of platycodin D in CIA mice.

Groups	Paw weights		Spleen weights		Left popliteal lymph nodes weights
	Absolute	Relative	Absolute	Relative	Absolute	Relative
Controls
Intact	0.133±0.008	0.667±0.022	0.047±0.008	0.236±0.028	0.003±0.002	0.013±0.009
CIA	0.202±0.027^a	1.195±0.188^a	0.101±0.009^a	0.599±0.075^a	0.015±0.004^a	0.088±0.025^a
Reference
Enbrel	0.136±0.004^c	0.665±0.037^c	0.062±0.004^ac	0.302±0.022^ac	0.005±0.004^c	0.025±0.020^c
Platycodin D
200 mg/kg	0.128±0.011^c	0.688±0.121^c	0.055±0.003^bc	0.291±0.022^ac	0.007±0.003^bc	0.036±0.017^bc
100 mg/kg	0.140±0.018^c	0.763±0.144^c	0.062±0.008^ac	0.335±0.047^ac	0.008±0.003^ac	0.041±0.015^ac
50 mg/kg	0.154±0.029^d	0.902±0.243^bd	0.074±0.019^ad	0.435±0.141^ad	0.011±0.003^ac	0.061±0.017^ac

Values are expressed as mean ± SD, g (absolute weight), or % (relative weights versus body weights at sacrifice) of eight mice. ^a𝑃<0.01 as compared with intact control by LSD test, ^b𝑃<0.01 and ^c𝑃<0.05 as compared with CIA control by LSD test, and ^d𝑃<0.01 as compared with intact control by MW test.