Effect of Integrated Cognitive Therapy on Hippocampal Functional Connectivity Patterns in Stroke Patients with Cognitive Dysfunction: A Resting-State fMRI Study

Table 4

Significant differences in functional connectivity of hippocampus in the ischemic stroke patients with cognitive dysfunction before and after the integrated cognitive therapy.

Anatomical regions	Side	Cluster size	Peak coordinates (MNI)			Peak -score
			Middle frontal gyrus^a	R	36		24	27	24	5.1236
Cerebellum posterior lobe^a	R	70	24	−78	−48	4.9730
Superior frontal gyrus^a	R	66	6	36	60	4.7074
Inferior frontal gyrus^a	L	40	−39	42	−12	4.6973
Precuneus^a	L	47	−15	−48	51	4.0605
Precuneus^b	L	67	−12	−69	39	3.6092
Medial frontal gyrus^b	R	89	15	45	3	3.5207
Inferior frontal gyrus^b	R	92	15	24	−15	3.3922
Middle frontal gyrus^b	L	89	−24	30	−18	3.3803
Insular cortex^b	L	38	−30	20	15	3.3789
Superior temporal gyrus^b	L	35	−36	6	0	3.3758

Changes about functional connectivity of the right hippocampus with all other brain voxels in this study. ^bChanges about functional connectivity of the left hippocampus with all other brain voxels in this study.
, corrected for multiple comparison. R: right side; L: left side.