In Vitro Antibacterial, Antifungal, Antibiofilm, Antioxidant, and Anticancer Properties of Isosteviol Isolated from Endangered Medicinal Plant Pittosporum tetraspermum
Table 1
Minimum inhibitory concentration of the compound against Gram positive and Gram negative bacteria.
Microorganism
Minimum inhibitory concentration (MIC) (g/mL)
Compound
Streptomycin sulfate
Gram positive
Bacillus subtilis (MTCC 441)
250
2.5
Staphylococcus aureus (ATCC 25923)
125
37.5
Staphylococcus epidermidis (MTCC 3615)
125
10
Enterococcus faecalis (ATCC 29212)
250
25
Gram negative
Escherichia coli (ATCC 25922)
62.5
25
Klebsiella pneumoniae (ATCC 15380)
125
25
Pseudomonas aeruginosa (ATCC 27853)
62.5
50
Multi drug resistant
Staphylococcus aureus (MMC/3)
>10.00
NT
Staphylococcus aureus (MMC/5)
>10.00
NT
Staphylococcus aureus (MMC/6)
10.00
NT
Staphylococcus aureus (MMC/9)
10.00
NT
Staphylococcus aureus (MMC/16)
10.00
NT
Staphylococcus aureus (MMC/17)
8.00
NT
Staphylococcus aureus (MMC/18)
8.00
NT
Staphylococcus aureus (MMC/19)
10.00
NT
Staphylococcus aureus (MMC/25)
10.00
NT
Staphylococcus aureus (MMC/28)
6.00
NT
Staphylococcus aureus (MMC/34)
8.00
NT
Staphylococcus aureus (MMC/45)
8.00
NT
Staphylococcus aureus (MMC/47)
8.00
NT
Staphylococcus aureus (MMC/49)
12.00
NT
MTCC: microbial type culture collection; ATCC: American type culture collection; MMC: strains from Madras Medical College; streptomycin: standard antibacterial agents; compound: isosteviol; NT: not test; for multi-drug resistant strains the concentrations of the compounds were tested in mg/mL level. Streptomycin did not show activity towards multi-drug resistant strains.
