Extra Virgin Olive Oil Polyphenols Promote Cholesterol Efflux and Improve HDL Functionality

<div>Tyrosol and hydroxytyrosol increase ABCA1 protein expression and enhance apoA-I-mediated cholesterol efflux. [<sup>3</sup>H]-Cholesterol-loaded J774 macrophages were incubated for 12 h with different concentrations (0 to 25 <i>μ</i>M) of tyrosol (a) or hydroxytyrosol (b) to generate ABCA1-enriched cells, which were then incubated with 25 <i>μ</i>g/mL of apo-AI for 4 h. Results are expressed as the means ± SEM of at least three independent experiments.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 4

Figure 4: Extra Virgin Olive Oil Polyphenols Promote Cholesterol Efflux and Improve HDL Functionality 