In Vivo and In Vitro Metabolites from the Main Diester and Monoester Diterpenoid Alkaloids in a Traditional Chinese Herb, the Aconitum Species

Table 7

DDA metabolites detected in the plasma.

DDAs	(ESI^+)	Formula	Identification	Metabolic procedure	MS detection	References
AC	604	C32H45NO10	BAC	Mouse; plasma; ig, in vivo.	GC/MS	[51]
				Rabbit; plasma; ig, in vivo.	IT	[52] (M2)
	590	C31H43NO10	16-O-Demethyl BAC	Rabbit; plasma; ig, in vivo.	IT	[52] (M3)
	500	C25H41NO9	Aconine	Rats; plasma; iv, in vivo.^a	Q-Trap	[39]
				Mouse; plasma; ig, in vivo.	GC/MS	[51]
				Rabbit; plasma; ig, in vivo.	IT	[52] (M4)
MA	590	C31H43NO10	BMA	Rats; plasma; iv, in vivo.^a	Q-Trap	[39]
	486	C24H40NO9	Mesaconine
HA	574	C31H44NO9	BHA	Rats; plasma; iv, in vivo.^a	Q-Trap	[39]

A mixture of AC, MA, and HA was administered via the tail vein.