Salutary Effects of Cepharanthine against Skeletal Muscle and Kidney Injuries following Limb Ischemia/Reperfusion

<div>Representative microscopic findings of the muscle and kidney tissues stained with hematoxylin and eosin (200x). The muscle injury score (% injury of skeletal muscle fibers) and the wet/dry weigh ratio in muscle and kidney. Sham: the sham group. Sham + CEP: the sham plus cepharanthine group. I/R: the limb ischemia-reperfusion group. I/R + CEP: the I/R plus cepharanthine group. CS: cross section. U: uninjured muscle fiber. I: injured muscle fiber. DMSO: dimethylsulfoxide. 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36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z" id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg><i> versus</i> the sham group. <svg height="15.3614pt" id="M15" style="vertical-align:-3.833899pt" version="1.1" viewbox="-0.0498162 -11.5275 49.7858 15.3614" width="49.7858pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z" id="g58-33"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,4.946,.966)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 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id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg>, the I/R + CEP<i> versus</i> the I/R group.</div>

Evidence-Based Complementary and Alternative Medicine

fig4

Figure 4

Figure 4: Salutary Effects of Cepharanthine against Skeletal Muscle and Kidney Injuries following Limb Ischemia/Reperfusion 