Herbal SGR Formula Prevents Acute Ethanol-Induced Liver Steatosis via Inhibition of Lipogenesis and Enhancement Fatty Acid Oxidation in Mice

Figure 7

Excessive consumption of alcohol can upregulate the expression of SREBP-1c and downregulate the expression of PPAR-α. Meanwhile, alcohol exposure also inhibits AMPK and subsequently increases ACC activity but decreases carnitine palmitoyltransferase 1 (CPT-1) activity. All of them lead to an increase in fatty acid synthesis and a decrease in fatty acid β-oxidation. Furthermore, alcohol exposure stimulates adipose tissue adipokine imbalance, such as adiponectin and TNF-α. Moreover, alcohol-induced also stimulates adipose tissue lipolysis, the triglycerides reverse transported and deposited in the liver. Moreover, herbal formula SGR contains abundant flavonoids, including dihydromyricetin, dihydroquercetin, and quercetin which inhibit lipogenesis to prevent ethanol-induced liver steatosis.