Shikonin Inhibits Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts via lncRNA-NR024118

Figure 6

Detection of SOCS3, IL-6, IL-8, MMP-1, and MMP-3 expression in NR024118 interfered MH7A cells. After being treated with 4 μM shikonin and normal incubation for 24 hours, enhanced SOCS3 expression levels were observed in IL-1 induced MH7A cells while this change could be recovered by NR024118 interference (a). When MH7A cells were treated with 4 μM shikonin, diminished IL-6, IL-8, MMP-1, and MMP-3 were detected, and this change could also be reversed by NR024118 interference (b). versus control. versus ethanol. versus si-control.

(a)

(b)