Yokukansan Increases 5-HT_1A Receptors in the Prefrontal Cortex and Enhances 5-HT_1A Receptor Agonist-Induced Behavioral Responses in Socially Isolated Mice

Figure 1

Yokukansan (YKS) cotreatment increased 5-H receptor binding in the prefrontal cortex (PFC) of isolation-stressed mice. Binding of a [³H]-labeled 5-H receptor agonist ([³H]8-OH-DPAT) in the PFC of group-housed mice (group), mice subjected to isolation stress alone (isolation), or isolation stress with 1% or 3% yokukansan cotreatment (ISO + YKS). (a) Saturation curves and (b) Scatchard plots. Each point is the mean of 10 independent measurements.

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