Yokukansan Increases 5-HT_1A Receptors in the Prefrontal Cortex and Enhances 5-HT_1A Receptor Agonist-Induced Behavioral Responses in Socially Isolated Mice

Figure 2

Yokukansan (YKS) cotreatment increased the 5-H receptor density (greater ) but reduced receptor affinity (higher ) in the PFC of isolation-stressed mice. Binding parameters determined by a [³H]-labeled 5-H receptor agonist ([³H]8-OH-DPAT). (a) and (b) . Each column shows the mean ± SEM (). Asterisks indicate a significant difference: , , and , versus isolation stress alone (0% YKS).

(a)

(b)