Effects of Electroacupuncture with Dominant Frequency at SP 6 and ST 36 Based on Meridian Theory on Pain-Depression Dyad in Rats

Figure 1

Experimental procedure. Right after the baseline pain threshold was tested, animals in the experimental groups and the normal group were administered reserpine injection or vehicle (0.2 mL/kg, subcutaneously), respectively, for three consecutive days. On the fourth day, PWL tests to examine mechanical allodynia were performed before and after the EA treatment, respectively. On the fifth day, another EA treatment was performed, followed by PWL test, EZM test, and OF test.