Synergistic Use of Geniposide and Ginsenoside Rg1 Balance Microglial TNF- and TGF-1 following Oxygen-Glucose Deprivation In Vitro: A Genome-Wide Survey

Figure 1

(a) Bar graphs show the changes in microglial cell viability determined by CCK-8 assay. A significant decrease in cell viability was observed when microglia were exposed to hypoxia, and viability increased when microglia were cultured with geniposide. Cell viability increased further when microglial cells were treated with the combination. (b) Bar graphs show the changes in NO content in microglial cultural medium. NO content in the model group was significantly increased compared with the control group. When treated with geniposide or ginsenoside Rg1 alone, the NO content was obviously suppressed. The NO content was suppressed further when microglia were treated with the combination. versus control, versus model, and versus model. Control, normal cultured microglial cells; Model, OGD-injured microglial cells; Gen, geniposide-treated microglial cells; Rg1, ginsenoside-Rg1-treated microglial cells; Gen+Rg1, combination-treated microglial cells.

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