UP3005, a Botanical Composition Containing Two Standardized Extracts of Uncaria gambir and Morus alba, Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model

Table 4

Change of BMD and architecture in MIA-induced rats treated with UP3005 orally.

	Normal	Vehicle	Diclofenac (10 mg/kg)	UP3005 (500 mg/kg)
BMD (mg/cm^3)	1023.5 ± 8.3	881.9 ± 64.0	982.3 ± 19.	996.1 ± 11.
BV/TV (%)	74.76 ± 2.60	68.24 ± 5.03	71.89 ± 5.43	70.84 ± 5.92
BS/BV (1/mm)	7.22 ± 0.65	8.76 ± 1.13	7.82 ± 0.98	8.03 ± 0.74
Tb. Th (mm)	0.28 ± 0.02	0.23 ± 0.03	0.26 ± 0.03	0.25 ± 0.02
Tb. Sp (mm)	0.094 ± 0.006	0.107 ± 0.012	0.100 ± 0.015	0.103 ± 0.02

Data represented as mean ± SD. (versus vehicle). BV/TV: total trabecular bone volume/total tissue (bone + marrow) volume; BS/BV: trabecular bone surface/trabecular bone volume; Tb. Th: trabecular thickness; Tb. Sp: trabecular spacing. = 10 rats/group.