Xuebijing Ameliorates Sepsis-Induced Lung Injury by Downregulating HMGB1 and RAGE Expressions in Mice

Figure 2

Xuebijing (XBJ) inhibits inflammation in the injured lung. (a) Representative histological lung sections from each group. Tissues were stained with hematoxylin and eosin (H & E). CLP-induced lung injury with morphological destruction and neutrophil infiltration at 6, 24, and 48 hours. These changes were significantly attenuated by treatment with XBJ (). Original magnification, ×100; HE, hematoxylin and eosin. (b) Lung injury score. The lung injury scores of inflammation on histology at 24 and 48 hours after CLP were significantly reduced by XBJ treatment. Data are expressed as means ± SEM for 8 mice per group. versus respective CLP group. CLP, caecal ligation and puncture.

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