Xuebijing Ameliorates Sepsis-Induced Lung Injury by Downregulating HMGB1 and RAGE Expressions in Mice

Figure 4

Inhibition effects of Xuebijing (XBJ) on neutrophils and inflammatory cytokines production in bronchoalveolar lavage (BAL) fluid of CLP-induced lung injury mice. (a) Total cell counts were performed. The BAL fluid was obtained from mice () at 6, 24, and 48 hours after CLP. (b) The neutrophil counts were performed. The neutrophil counts were performed on a minimum of 500 cells to identify neutrophils. ((c)–(e)) Cytokines (IL-6, IL-1β, and TNF-α) in the BAL fluid were measured by ELISA at 6, 24, and 48 hours after CLP. Data are expressed as means ± SEM for 8 mice per group. versus respective sham group; versus respective CLP group; versus respective CLP group. CLP, caecal ligation and puncture.

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