Xuebijing Ameliorates Sepsis-Induced Lung Injury by Downregulating HMGB1 and RAGE Expressions in Mice

Figure 5

Inhibition of Xuebijing (XBJ) on HMGB1 and RAGE expression. (a) Western blot analysis of HMGB1 in the lungs. (b) Western blot analysis of RAGE in the lungs. (a)-(b) Representative western blot image (upper panel) and quantification (lower panel) analysis are shown. (c) HMGB1 in serum was measured by ELISA at 6, 24, and 48 hours after CLP. Data are expressed as means ± SEM for 8 mice per group. versus respective sham group; versus respective CLP group; versus respective CLP group. CLP, caecal ligation and puncture. HMGB1, high mobility group box protein 1. RAGE, receptor for advanced glycation end products.

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