Systemic Review and Meta-Analysis of the Clinical Efficacy and Adverse Effects of Zhengqing Fengtongning Combined with Methotrexate in Rheumatoid Arthritis

Table 1

Characteristics of the included studies.

Author, year	Sample size		Intervention methods		Duration	Outcomes
	EG	CG	EG	CG	(wks)
Lao 2000 [8]	32	32	ZQFTN 20–40 mg tid, MTX 7.5 mg qw	MTX 15 mg qw	12	TE, TJC, SJC, DMS, RF, ESR, AE
Wu 2003 [9]	40	40	ZQFTN 40 mg tid, MTX 7.5 mg qw	MTX 15 mg qw	12	TE, TJC, SJC, DMS, RF, ESR, AE
Sun and Lan 2006 [10]	62	58	ZQFTN 120 mg qd, MTX 15 mg qw	MTX 15 mg qw	24	TE, RF, ESR, CRP, AE
Ji and Zhu 2006 [11]	30	30	ZQFTN 20–40 mg tid, MTX 7.5 mg qw	MTX 15 mg qw	12	TE, TJC, SJC, DMS, RF, ESR, CRP, AE
Ding 2010 [12]	31	31	ZQFTN 20–40 mg tid, MTX 7.5 mg qw	MTX 15 mg qw	12	TE
Huang and Wang 2010 [13]	30	30	ZQFTN 60 mg bid, MTX 7.5 mg qw	MTX 15 mg qw	12	TE, TJC, SJC, DMS, RF, ESR, CRP, AE
Xia et al. 2012 [14]	52	52	ZQFTN 60 mg tid, MTX 10 mg qw	MTX 10 mg qw	12	TE, TJC, SJC, DMS, RF, ESR, CRP, AE
Zhu et al. 2013 [15]	36	36	ZQFTN 60 mg bid, MTX 10 mg qw	MTX 10 mg qw	24	TE, TJC, SJC, DMS, ESR, CRP, AE
Li et al. 2008 [16]	35	34	ZQFTN 120 mg bid, MTX 10 mg qw	MTX 15 mg qw	8	TE, DMS, RF, ESR, CRP, AE
Wang 2010 [17]	120	66	ZQFTN 120 mg bid, MTX 10 mg qw	MTX 10 mg qw	24	TE, DMS, RF, ESR, CRP, AE
Lu and Su 2011 [18]	40	39	ZQFTN 120 mg bid, MTX 10 mg qw	MTX 10 mg qw	12	TE, TJC, RF, ESR, CRP, AE

Note: ZQFTN: Zhengqing Fengtongning; EG: experimental group; CG: control group; TE: total effect; TJC: tender joint count; SJC: swollen joint count; DMS: duration of morning stiffness; RF: rheumatoid factor; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; AE: adverse effect.