The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function

Figure 4

Brain concentrations versus time profiles of (a) oseltamivir and (b) oseltamivir carboxylate (OC) after the administration of oseltamivir phosphate (OP) to mice with lipopolysaccharide- (LPS-) induced inflammation. Mice were pretreated with three intraperitoneal (i.p.) injections of LPS (3 mg/kg) with concurrent oral administration of (●) saline (control), (□) maoto, or (△) kakkonto. A single oral dose of OP (300 mg/kg) was administered to mice 120 min after the third injection of LPS. Horizontal bar represents the mean values. and (versus control), Tukey-Kramer test.

(a) Oseltamivir

(b) OC