Andrographolide Enhances Proliferation and Prevents Dedifferentiation of Rabbit Articular Chondrocytes: An In Vitro Study

Figure 7

Quantitative comparison of extracellular-matrix-related gene expression by qRT-PCR. Chondrocytes were cultured with 0 (Control), 1.5 (T1), 3 (T2), and 6 μM (T3) ANDRO for 2 days (a), 4 days (b), and 6 days (c) ( for each group at a certain time point). Gene expression levels in AND groups relative to the control group were analyzed by the method using GAPDH as the internal control. Isoforms of collagen type I, type II, and type X studied are COL1A1, COL2A1, and COL10A1, respectively. The data reported as mean ± SD. , ∧ indicate ; , ∧∧ indicate ; , ∧∧∧ indicate .

(a)

(b)

(c)