Intra-Articular Hyaluronic Acid Compared to Traditional Conservative Treatment in Dogs with Osteoarthritis Associated with Hip Dysplasia

Table 5

Helsinki Chronic Pain Index (HCPI) scores, Canine Brief Pain Inventory (CBPI) scores referring to total pain scores (TPS), pain severity scores (PSS), pain interference scores (PIS), and the scores evaluated by the veterinarian prior to treatment (i.e., baseline) and over time in dogs treated with intra-articular hyaluronic acid (Hyal, ) or traditional conservative treatment (Control, ).

Variables	Groups	Time of assessment					⁢ value
		Baseline	15 days	30 days	60 days	90 days
HCPI score	Hyal
% change			28%	27%	40%	43%
HCPI score	Control
% change			31%	22%	29%	24%
CBPI TPS	Hyal
% change			36%	50%	54%	64%
CBPI TPS	Control
% change			32%	31%	28%	28%
^# value					0.03	0.02
CBPI PSS	Hyal
% change			30%	40%	40%	49%
CBPI PSS	Control
% change			31%	33%	30%	27%
CPBI PIS	Hyal
% change			30%	40%	40%	49%
CPBI PIS	Control
% change			30%	30%	31%	32%
^# value					0.02	0.02
Vet score	Hyal
% change			42%	56%	64%	57%
Vet score	Control
% change			24%	20%	13%	13%
^# value			0.01	0.001	0.001	0.002

Note: data are expressed as mean ± standard deviation (SD). Significantly different from baseline values. ^#Significantly different from Control group. ANOVA with posttest Tukey-Kramer multiple comparisons test ().