Research Article

iTRAQ-Based Proteomic Analysis of Ginsenoside F2 on Human Gastric Carcinoma Cells SGC7901

Table 1

Differentially upregulated (>1.20-fold) proteins identified by iTRAQ in F2 treated SGC7901 cells.

Rank #AccessionGene symbol (GN)Definition (description)ScoreMassCov%RationCOG function-description

Up 1sp|P07305-2H1F0Isoform 2 of histone H1.05135582132.11
Up 2sp|P20962PTMSParathymosin5031578223.51.32
Up 3tr|B8ZWD1DBIDiazepam binding inhibitor, splice form 1A(2)1211570628.91.31Acyl-CoA-binding protein
Up 4sp|Q16576RBBP7Histone-binding protein RBBP78775573724.51.25FOG: WD40 repeat
Up 5sp|P46779-2RPL28Isoform 2 of 60S ribosomal protein L285242210727.61.35
Up 6tr|B2R514cDNA, FLJ92300, Homo sapiens COP9 subunit 6 (MOV34 homolog, 34 kD) (COPS6), mRNA743906820.21.22Predicted metal-dependent protease of the PAD1/JAB1 superfamily
Up 7tr|B3KY12cDNA FLJ46581 fis, clone THYMU3043200, highly similar to splicing factor 3A subunit 352771859221.24Splicing factor 3a, subunit 3
Up 8sp|Q71DI3HIST2H3AHistone H3.26171969426.51.40Histones H3 and H4
Up 9tr|Q9P0H9RER1RER1 protein11828927221.26Golgi protein involved in Golgi-to-ER retrieval
Up 10tr|A8K3Q9cDNA FLJ76611, highly similar to Homo sapiens ribosomal protein L14 (RPL14), mRNA7813511425.92.24Ribosomal protein L14E/L6E/L27E
Up 11sp|Q9Y3A2UTP11LProbable U3 small nucleolar RNA-associated protein 11944417421.71.30Uncharacterized conserved protein
Up 12tr|F2Z388RPL3560S ribosomal protein L35991537232.31.35Ribosomal protein L29
Up 13sp|Q9NZZ3CHMP5Charged multivesicular body protein 526832218211.42
Up 14tr|B2R4D860S ribosomal protein L2739823061361.28Ribosomal protein L14E/L6E/L27E
Up 15tr|M0QXF7C19orf10UPF0556 protein C19orf10 (fragment)26511851251.24
Up 16tr|D3DV26S100A10S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (P11)), isoform CRA_b (fragment)134279358.31.21
Up 17tr|H7C2N1PTMAThymosin alpha-1 (fragment)117182838.81.30
Up 18tr|G2XKQ0Sumo13601493811.91.22Ubiquitin-like protein (sentrin)
Up 19tr|I3L1Y9FLYWCH2FLYWCH family member 2991930247.21.45
Up 20tr|M0R210RPS1640S ribosomal protein S1611051939157.41.27Ribosomal protein S9
Up 21sp|O43715TRIAP1TP53-regulated inhibitor of apoptosis 1821205018.41.36
Up 22sp|P49207RPL3460S ribosomal protein L341871868420.51.66Ribosomal protein L34E
Up 23sp|Q92522H1FXHistone H1x3423525025.41.33
Up 24tr|J3KRX5RPL1760S ribosomal protein L17 (fragment)7952738238.51.26Ribosomal protein L22
Up 25sp|P02795MT2AMetallothionein-2104991552.51.42
Up 26tr|Q6FIE5PHP14PHP14 protein72173018.81.27
Up 27tr|A0PJ62RPL14RPL14 protein (fragment)5362140943.52.85Ribosomal protein L14E/L6E/L27E
Up 28tr|G3XAA2MAP4K4Mitogen-activated protein kinase kinase kinase kinase 41421569892.71.24Serine/threonine protein kinase
Up 29tr|C9JNW5RPL2460S ribosomal protein L2466624642321.67Ribosomal protein L24E
Up 30sp|Q13951CBFBCore-binding factor subunit beta1972446118.11.20
Up 31tr|D3DUE6N-PACCytokine-like nuclear factor n-pac, isoform CRA_c2197672814.51.243-Hydroxyisobutyrate dehydrogenase and related beta-hydroxy acid dehydrogenases
Up 32tr|K7EKW4ISOC2Isochorismatase domain-containing protein 2, mitochondrial (fragment)1302120217.41.34Amidases related to nicotinamidase
Up 33sp|Q9NQ55-2PPANIsoform 2 of Suppressor of SWI4 1 homolog736371310.71.37
Up 34tr|B3KMF8cDNA FLJ10869 fis, clone NT2RP40016771271239827.71.28
Up 35sp|P62424RPL7A60S ribosomal protein L7a6134231627.11.78Ribosomal protein HS6-type (S12/L30/L7a)
Up 36tr|B4E0X1Beta-2-microglobulin1851709313.11.25
Up 37tr|H0Y7A7CALM2Calmodulin (fragment)7352420930.51.26Ca2+-binding protein (EF-Hand superfamily)
Up 38tr|J3KTJ8RPL2660S ribosomal protein L26 (fragment)36315545341.24Ribosomal protein L24
Up 39tr|B4DJM5cDNA FLJ61294, highly similar to keratin, type I cytoskeletal 173262129124.91.46
Up 40sp|Q9Y3C1NOP16Nucleolar protein 16792792520.81.24
Up 41sp|Q16543CDC37Hsp90 cochaperone Cdc373845773029.61.22
Up 42sp|P16401HIST1H1BHistone H1.58014264417.32.38
Up 43sp|Q07866-3KLC1Isoform G of kinesin light chain 16428182823.91.24FOG: TPR repeat
Up 44tr|B4DKJ4cDNA FLJ57738, highly similar to translationally controlled tumor protein3441925032.41.28