Protective Effect of Yinhua Miyanling Tablet on Lipopolysaccharide-Induced Inflammation through Suppression of NLRP3/Caspase-1 Inflammasome in Human Peripheral Blood Mononuclear Cells

Table 1

Significantly downregulated inflammation-related genes in PBMC following YMT treatment for 18 h.

Number	Gene name	M/N	Y/M	Description
1	CASP1	2.00	−2.03	Caspase 1, apoptosis-related cysteine peptidase
2	CCL2	2.28	−2.94	Chemokine (C-C motif) ligand 2
3	CHUK	2.54	−2.01	Conserved helix-loop-helix ubiquitous kinase
4	FADD	2.68	−4.40	Fas (TNFRSF6) associated via death domain
5	HSP90AB1	5.74	−2.68	Heat shock protein 90 kDa alpha, class B member 1
6	IKBKG	3.42	−2.03	Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma
7	IRF1	4.96	−5.13	Interferon regulatory factor 1
8	NFKBIA	3.65	−3.33	Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
9	NLRP1	2.48	−3.41	NLR family, pyrin domain containing 1
10	NLRP3	3.13	−2.17	NLR family, pyrin domain containing 3
11	PEA15	2.55	−2.53	Phosphoprotein enriched in astrocytes 15
12	RELA	4.75	−2.11	V-rel reticuloendotheliosis viral oncogene homolog A (avian)
13	RIPK2	2.37	−2.44	Receptor-interacting serine-threonine kinase 2
14	TNF	6.06	−3.65	Tumor necrosis factor
15	TXNIP	2.68	−3.71	Thioredoxin interacting protein