A Transmembrane Polymorphism of Fcγ Receptor IIb Is Associated with Kidney Deficiency Syndrome in Rheumatoid Arthritis

Table 6

Frequency of the FcγRIIb IIe232Thr polymorphism in patients with kidney deficiency and no kidney deficiency.

Genotype frequency	Kidney deficiency	No kidney deficiency			OR	95% CI
Individual genotype
I232II	76 (47.8%)	125 (77.6%)			1
I232IT	73 (45.9%)	35 (21.7%)	24.96	0.000^†	3.43	2.09–5.62
I232TT	10 (6.3%)	1 (0.6%)	12.20	0.000^†	16.45	2.06–131.04
Pooled genotype analysis
I232II	76 (47.8%)	125 (77.6%)
I232IT + I232TT	83 (52.2%)	36 (22.3%)	30.50	0.000^‡	3.79	2.34–6.15
Allele frequency
T	285 (88.51%)	225 (70.75%)	31.16	0.000^‡	3.18	2.09–4.84
I	37 (11.49%)	93 (29.25%)

By chi-square test with 3 × 2 contingency tables analysis (2 degrees of freedom (df)).
Calculated using the chi-square test for 2 × 2 contingency tables analysis (df).
The odds ratio (OR) and 95% confidence interval (95% CI) were calculated in comparison with the wild type.