Evidence-Based Complementary and Alternative Medicine

Review Article

Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review

Table 2

Biases analyses (ARRIVE) of the studies of the effects of fractions and isolates from the plants in the treatment of the type II diabetes.
 IsolatesFractions  
References Miura, et al., 2001 [26] Kavishankar and Lakshmidevi, 2014 [27] Moser et al., 2014 [28] Chen et al., 2009 [38] Ruan et al., 2012 [29] Sato et al., 2002 [30] Lo et al., 2006 [31] Yoshida et al., 2013 [32] Zhao et al., 2014 [34] Kumar et al., 2012 [40] Luo et al., 1999 [36] Perez-Gutierrez and Damian-Guzman, 2012 [35] Kwon et al., 2012 [37] Krenisky et al., 1999 [33] Hsu  et al., 2014 [39] Ren et al., 2015 [25] Agrawal et al., 2013 [42] Zhang et al., 2013 [41] Jeong and Song, 2011 [1] Chakrabarti et al., 2005 [44] Paramaguru et al., 2014 [43] Kiho et al., 2001 [45] Fujii et al., 2009 [46] Chen et al., 2013 [47] Arya et al., 2012 [49] Klomann et al., 2010 [48] Arya et al., 2012 [49] Xu et al., 2015 [17] Ibrahim and Islam, 2014 [50] Ganeshpurkar et al., 2014 [51] Shu et al., 2009 [52] Zhao et al., 2005 [54] Hwang et al., 2009 [55] Wu et al., 2005 [56] Xu et al., 2011 [57] Costantino et al., 2003 [58] Yu et al., 2015 [61] Kharbanda et al., 2014 [60] Roman-Ramos et al., 2012 [53]   
Accurate and concise description of the content of the article XXXXXXXXXX XX XX  XX XXXXXXXXXXXXXXXXX3384.62%
Abstract                                         
Summary of the background, research objectives, methods, main findings, and conclusionsXXXXX XXXXXXXXXXXXX  XXXXXXXXXXXXXXXXXX3692.30%
Introduction                                         
Sufficient scientific backgroundXXXXX XXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXX3794.87%
Explanation of the experimental approach and rationale XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX X3794.87%
Objectives                                         
Clear primary and second objectivesXXXX  XXXXX XXXXXX XXXX  XXXXXXXXX XXXX3282.05%
Material and methods                                         
Ethical statement                                         
Nature of the ethical review permissions and institutional guidelines for the care and use of animals XXXXXXXXXXXXXXXXXX XX XXXXXXXXXXXXXXXX3692.3%
Study design                                         
Number of animals per group XXX  XXXXXXXX X   XX  XXXXXXX XXXXXXXX2974.35%
Information on whether the experiment was performed as a blind controlled study    X  X              X   X     X   X  615.38%
Experimental procedures                                         
TreatmentXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX39100.00%
Dosage of treatmentXXXXXXXXXXXX XXXXXXXXXX XXXXXXXXXXXXXXX3794.87%
Route of administrationXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXX3897.44%
Duration of treatmentXXXX XX  XXX XXXXXXXXXXXXXXXXXXXXXXXXXX3589.74%
Time of day for treatment administration X         X     XXX  XX      X    X   923.07%
Location used for administration of treatment                           X           12.56%
Rationale for choice of specific dosage    X X X  XX X    XX X         X  X  X1230.76%
Rationale for choice of specific route of administration    X X X                          X XX615.38%
Experimental animals                                         
Information on animal speciesXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXX  XX 3589.74%
Strain of the animals X  XXXXXXX X  XXXXXXXXXXX  XXXXXX  XXX2974.36%
Sex of the animalsXXXXXXXXXXXXXXXXXX XXXXXXXXXXX XXX XXXX3692.30%
Animals weight range X    X    X X XXX XXX XX XXX XXXX  XXX2256.41%
Age of the animalsX XXXX  X X XXXX  XX XX XX  X   XXX X  2256.41%
Description of genetic modification status (knock-out, transgenic, and SPF)X XX    XXX   X  XX  XX    X    XX XXXX1846.15%
Information related to previous procedures performed on the animals XXXXXXX  XXXXX  XXXXXXXX X      X  XXX2564.10%
Housing and husbandry                                         
Housing of experimental animals (type of facility, type of cage or housing, material, and number of cage companions)  X   XX  XXX  X  X X    XXXX       X  1435.89%
Husbandry conditions (breeding programme, light/dark cycle, and temperature of water) XXXX XX XXXXXXXX XXXXXXXXXXXXXXXXX X X3384.62%
Welfare-related assessments and interventions that were carried out before, during, or after the experiment      X            XX X             X  512.82%
Sample size                                         
Total number of animals used in each experiment and the number of animals in each experimental group XXX  XXXX XX  X    X XXXXXXXX X  X X  2256.41%
Explanation regarding the decision of the number of animals and details of sample size calculation      X                         X      25.12%
Allocation of animals into experimental groups                                         
Full details of how animals were allocated to experimental groups (including randomization or matching)   X  X X   X    X    X X  XX  X    X  1128.20%
Order in which the animals in the different experimental groups were treated and assessedXXXXX XXX XX     XXXXXXXXXXX X  XXX XXX2871.79%
Experimental outcomes                                         
Clear experimental outcomes assessed XXXX XXXXXX X      XXXXXXXXXXXXXX  XXX2871.79%
Statistical methods                                         
Statistical methods used for each analysisXXXXX XXXX  XXXXXXXXXXXXXXXXX XXXXX XXX3487.18%
Specification of the unit of analysis for each dataset   XX XXXX XXXXXXXXXXXXXXXXXXXXXXXX XXX3384.61%
Methods used to assess whether the data met the assumptions of the statistical approachXXXXX XXXX XXX XXXXXXXXXXXXXXXXXXX  XXX3487.18%
Results                                         
Baseline data                                         
Description of the animals health status, for each experimental group, before treatmentXXXX    XX       XXXXXXX  X X  X X  X  1846.15%
Number analyzed                                         
Number or animals in each group included in each analysis (absolute numbers)      XX X     X         XX X  XXX  X X1230.76%
Animals or data not included in the analysis (and explanation for the exclusion)                                 X     12.56%
Outcomes and estimation                                         
Information (mean = standard deviation)XXXXX      XX    XXXXXXXX       XX  XXX2051.28%
Information on quantification of inflammatory cells (mean = standard deviation)                       X               12.56%
Adverse events                                         
Information on mortality of experimental animal (mean = standard deviation)  X                 X          X       37.69%
Modifications to the experimental protocols made to reduce adverse events  X                                 X  25.12%
Discussion                                         
Interpretation/scientific implications                                         
Interpretation of the results, taking into account the study objectives and hypothesesXXXX XXXXXXXXXX XXXXXXXXXXXXXXXXXX  XXX3589.74%
Comments on the study limitations (sources of bias and imprecision associated with the results) XX  XX XX         X            XX  XXX1230.76%
Generalizability /translation                                         
Comments on how the findings are likely to translate to other species or systems (relevance to human biology)  XXXXXXXX XX XXXX    X  XX     XX  XXX2256.41%
Funding                                         
List of funding sources and the role of the funder(s) in the study XXX     X  XXXXX XXX XXXXXXXXXXXX XXXX2871.79%
Results172831292415332628272325272320242124222729253227272729272822212532321617382630