Neuroprotective Effect of Paeonol Mediates Anti-Inflammation via Suppressing Toll-Like Receptor 2 and Toll-Like Receptor 4 Signaling Pathways in Cerebral Ischemia-Reperfusion Injured Rats

Table 1

Physiological parameters.

	BT; (°C)	HR; (beats/min)	MABP; (mmHg)	pH	pO2; (mmHg)	pCO2; (mmHg)	BS; (mg/dl)
Preischemia 10 min
Sham	36.9 ± 0.5	328.3 ± 27.1	96.9 ± 12	7.41 ± 0.04	401.0 ± 94.6	41.3 ± 8.3	128.6 ± 26.6
Control	37.2 ± 0.5	357.0 ± 46.2	100.8 ± 8.8	7.43 ± 0.03	411.9 ± 54.7	42.6 ± 4.5	139.4 ± 34.3
Paeonol	36.9 ± 0.5	346.8 ± 51.1	97.4 ± 9.5	7.42 ± 0.03	434.3 ± 49.6	41.9 ± 4.8	131.9 ± 30.3
Ischemia 60 min
Sham	34.8 ± 0.7	323.6 ± 69.3	90.3 ± 10.7	7.29 ± 0.12	394.1 ± 97.2	56.3 ± 18.9	115.1 ± 29.4
Control	35.2 ± 0.6	364.3 ± 46.0	92.9 ± 10.0	7.32 ± 0.07	408.9 ± 51.9	52.5 ± 12.0	123.4 ± 36.4
Paeonol	35.1 ± 0.7	346.3 ± 44.9	90.2 ± 7.90	7.33 ± 0.07	404.3 ± 62.6	49.0 ± 11.0	120.1 ± 28.6
Reperfusion 10 min
Sham	35.3 ± 0.9	317.9 ± 65.2	96.4 ± 19.7	7.33 ± 0.10	378.7 ± 128.7	53.0 ± 16.1	53.0 ± 16.1
Control	35.5 ± 0.8	346.3 ± 55.4	93.1 ± 9.3	7.34 ± 0.06	412.3 ± 73.2	50.9 ± 9.6	50.9 ± 9.6
Paeonol	35.5 ± 0.5	348.9 ± 33.0	95.3 ± 5.9	7.34 ± 0.06	360.8 ± 110.3	43.4 ± 9.1	43.4 ± 9.1

Physiological parameters are expressed as mean ± SD ( for each group) and were measured 10 min before and 60 min after occluding the blood flow of the right middle cerebral artery and 10 min after reperfusion. Sham: sham group; control: control group; paeonol: paeonol group; BT: body temperature; HR: heart rate; MABP: mean arterial blood pressure; BS: blood sugar.