Antioxidant and Wound Healing Activity of Polyherbal Fractions of Clinacanthus nutans and Elephantopus scaber
Table 2
Mean area of wound (mm2) and % wound contraction during excision wound model.
Days
Day 0 (before treatment)
3
6
9
12
15
17
Group 1 (ethyl acetate)
229 ± 1.47 (0.00)
169.5 ± 2.10 (25.98)
90.25 ± 1.70 (60.58)
61.50 ± 1.84 (73.14)
19.50 ± 0.95 (91.48)
0.00 ± 0.00 (100)
0.00 ± 0.00 (100)
Group 2 (n-butanol)
231.25 ± 3.30 (0.00)
147 ± 1.22 (36.43)
117.5 ± 1.04 (49.18)
48 ± 1.22 (79.24)
21 ± 2.41 (90.91)
0.00 ± 0.00 (100)
0.00 ± 0.00 (100)
Group 3 (aqueous)
233.5 ± 5.89 (0.00)
171.5 ± 4.25 (26.55)
118 ± 3.36 (49.46)
109.5 ± 2.21 (53.10)
74.25 ± 1.93 (68.20)
28.50 ± 3.27 (87.79)
0.00 ± 0.00 (100)
Group 4 (cream)
228.25 ± 4.23 (0.00)
196 ± 2.94 (14.12)
140.75 ± 3.06 (38.33)
88 ± 1.22 (61.44)
59.5 ± 1.65 (73.93)
28.25 ± 1.18 (87.62)
0.00 ± 0.00 (100)
Group 5 (control)
229.25 ± 2.45 (0.00)
203.25 ± 2.49 (11.43)
118 ± 3.13 (48.52)
93.75 ± 3.75 (59.10)
84.5 ± 3.5 (63.14)
54 ± 4.08 (76.44)
30.5 ± 3.86 (86.69)
Group 6 (standard)
231.29 ± 4.73 (0.00)
148.25 ± 1.93 (35.89)
89.25 ± 2.28 (61.40)
44.25 ± 2.28 (80.86)
18.5 ± 2.72 (92)
0.00 ± 0.00 (100)
0.00 ± 0.00 (100)
Values are mean ± SEM (percent) of 4 rats in each group. , , and compared to respective day control group (statistical analysis was done by one-way analysis of variance followed by Dunnett’s test for multiple comparisons).
