Comparative Study of Chemical Composition and Biological Activity of Yellow, Green, Brown, and Red Brazilian Propolis

Table 2

IC₅₀ (µg/mL) and selectivity index (SI) for brown, red, and yellow propolis extracts against a panel of tumour cells and against a normal cell L929.

⁢Tumour cells									Nontumour cells
	⁢SF-295		⁢HCT-116		⁢OVCAR-8		⁢HL-60		L929
	IC50	SI	IC50	SI	IC50	SI	IC50	SI
EEP-BPR	27.91; (26.88–28.98)	7.77	19.43; (16.52–22.84)	11.17	26.97; (25.81–28.19)	8.05	9.44; (8.67–10.28)	22.99	217; (101.9–461.8)
EEP-RBA	70.66; (9.06–551.0)	20.20	42.53; (14.93–121.2)	20.20	53.46; (44.30–64.52)	16.07	17.48; (14.66–20.85)	49.15	859.1; (137.5–5368)
EM-YMS	16.4; (11.6–23.1)	1.84	43.73; (32–59)	0.69	20.67; (18.7–38)	1.46	31.56; (22.4–44.4)	0.95	30.11; (23.45–38.66)
EEP-YMS	34.77; (25–48.3)	0.91	>50	—	17.9; (17.63–52.65)	1.70	>50	—	31.58; (21.29–46.87)
Dox	0.145; (0.127–0.162)	2.71	0.063; (0.046–0.081)	6.03	0.26; (0.16–0.30)	1.46	0.011; (0)	34.54	0.38; (0.28–0.48)

Only for yellow propolis an extract was also obtained with methanol as extractive solvent.