Endothelium-Dependent Vasorelaxant Effects of Dealcoholized Wine Powder of Wild Grape (<i>Vitis coignetiae</i>) in the Rat Thoracic Aorta

<div>The effects of endothelial receptors antagonist on WGWP-induced vasorelaxation in rat aortic rings. We pretreated endothelial receptors antagonists, atropine (muscarinic receptor antagonist, 1.0 <i>μ</i>M), diphenylhydramine (histamin receptor antagonist, 10 <i>μ</i>M), propranolol (bradykinin receptor antagonist, 1.0 <i>μ</i>M), and [D-Pro<sup>2</sup>, D-Trp<sup>7,9</sup>] substance P (substance P receptor antagonist, 5 <i>μ</i>M), for 20 min and constricted rat aortic rings by 300 nM norepinephrine. Then, vasorelaxation was measured after treatment with WGWP 1.0 mg/mL. <svg height="15.672pt" id="M11" style="vertical-align:-3.834pt" version="1.1" viewbox="-0.0498162 -11.838 48.9902 15.672" width="48.9902pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M682 0V33C615 38 603 49 571 134C507 305 441 494 378 665L343 655L136 136C101 48 86 41 22 33V0H246V33C170 41 161 50 183 112C196 152 209 192 224 232H441C461 176 478 126 493 87C504 49 499 41 433 33V0H682ZM425 279H242C273 363 303 448 335 533H337L425 279Z" id="g58-63"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="703" vert-adv-y="703"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,6.397,-5.741)"><path d="M98 134C72 134 46 117 46 90C46 73 55 65 60 64C95 55 124 32 124 -4C124 -42 95 -68 44 -89L57 -123C122 -104 194 -60 194 22C194 94 136 134 98 134Z" id="g50-45"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="237" 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Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: Endothelium-Dependent Vasorelaxant Effects of Dealcoholized Wine Powder of Wild Grape (<i>Vitis coignetiae</i>) in the Rat Thoracic Aorta 

Evidence-Based Complementary and Alternative Medicine

Endothelium-Dependent Vasorelaxant Effects of Dealcoholized Wine Powder of Wild Grape (Vitis coignetiae) in the Rat Thoracic Aorta

Figure 3