Epigenetic Profiling of H3K4Me3 Reveals Herbal Medicine Jinfukang-Induced Epigenetic Alteration Is Involved in Anti-Lung Cancer Activity

Figure 3

Gene Ontology analysis of JFK-induced A549 cell H3K4Me3 modification altered genes. (a) ChIP tag density profiles of H3K4Me3 modification at TSSs on MYC and EGFR genes. Fold change of MYC and EGFR H3K4Me3 modification status are detected by ChIP-qPCR (, ). (b) Heat map of top 2000 H3K4Me3 modification altered genes from upregulation and downregulation, respectively, in A549 cells with or without JFK treatment (). (c) KEGG pathway analysis of upregulated and downregulated genes.

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