Epigenetic Profiling of H3K4Me3 Reveals Herbal Medicine Jinfukang-Induced Epigenetic Alteration Is Involved in Anti-Lung Cancer Activity

Figure 6

Analysis of JFK-induced H3K4Me3 pattern and mRNA levels alteration in human lung cancer cell lines. Cells were treated with JFK for 48 h and fold change of H3K4Me3 modification was detected by ChIP-qPCR (). (a) NCI-H1975 cell line. (b) NCI-H1650 cell line. (c) NCI-H2228 cell line. Cells were treated with JFK for 48 h and the mRNA levels of SUSD2, CCND2, BCL2A1, and TMEM158 were detected by RT-qPCR (). (d) Fold change of SUSD2 and CCND2 expression. (e) Fold change of BCL2A1 and TMEM158 expression.

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